• Pop: 159
• Mayor: Angela Clyburn - Village Chairman , City offices - PO Box 26, - City Hall 573-223-2832
• City Clerk: Ravin Allen
• City Treasurer: None
• Education: Public-Clearwater R-1, K-12, in Piedmont, 8 mi., Private-Victory Baptist Academy in Piedmont, 8 mi.
• Healthcare: Nearest hospitals - 45 mi. in Poplar Bluff
• Recreation: Black River, Clearwater Lake

Mill Spring, a village of 159 according to the 2020 census, is situated in the southwestern portion of Wayne County. Average temperatures range from 26 degrees Fahrenheit in January to 91 degrees Fahrenheit in July. Ozark Foothills Regional Planning Commission works with the village to foster economic development for Mill Spring.

Angela Clyburn is the Chairman of the Board of Trustees of the village. Citizens are protected by the Wayne County Volunteer Fire Department. The median household income of Mill Spring, as reported in 2020, was $24,375.

Out of a 7,004-person workforce in Wayne County, the unemployment rate is 8.3 percent as of 2020. The average hourly wage for the county is $15.36. In nearby Piedmont, McAllister Software, Windsor, Clark's Mountain Nursing Center and Z manufacturing can be found. The county's other major employers include Greenville Schools and Clearwater Schools, which employs 160; Greenville Healthcare employs 49. 

Black River Electric Cooperative in Fredericktown and Ozark Border Electric Cooperative in Poplar Bluff provides electric power for Mill Spring. Natural Gas is provided by Liberty Utilities in Caruthersville. Telephone and internet services are provided by Windstream, AT&T, Big River, Boycom, and Windstream. 

Residents of Mill Spring travel 30 miles for health care. The nearest healthcare facilities are in Poplar Bluff at Coppertop, Pershing Veterans Administration Medical Center, and the Poplar Bluff Regional Medical Center, in Greenville at Greenville Family Clinic, in Piedmont at the Piedmont Family Clinic and Wayne Medical Center.

Mill Spring residents utilize Missouri Highways 49, 34, and 143. It is 18 miles to the nearest four-lane highway and Interstate 55 is 75 miles east. The nearest airport is in Piedmont.

The nearest public community college, Three Rivers College, is located in Poplar Bluff with approximate enrollment as 2,700 students. Poplar Bluff Area Technical Career Center is available for students seeking training in vocational skills. Southeast Missouri State University, a public four-year college located in Cape Girardeau, MO, is the nearest higher learning facility. 

Mill Spring residents keep up with local news through a weekly newspaper. There is a country club and two public tennis courts within a 20-mile radius for the enjoyment of young and old alike.

Clearwater Lake, Wappapello Lake and Black River are popular attractions for locals as well as visitors from all over the state. Everyone can enjoy camping, fishing, hiking/fitness/nature trails, boating, swimming and water skiing. Annual rainfall for the area averages 42 inches a year.

The community is represented by 144th District State Representative Chris Dinkins (R) and 25th District State Senator Jason Bean (R). U.S. Representative Jason Smtih (R) represents Mill Spring in the Eighth Congressional District.