• Class: 3
• County Seat: Greenville
• Pop: 10,974 (2020)
• Value: $148,238,767 (2021)
• Sq Mi: 763
• Presiding Commissioner: Brian Polk, Courthouse located at 109 Walnut St. in Greenville
• Major Employers: Windsor Foods, McAllister Software, Greenville Healthcare Center, State Parks, Public School Systems
• Education: 4 public systems, 2 private systems
• Healthcare: Greenville Family Clinic, Wayne Medical Center, Piedmont Family Clinic
• Transportation: 15 miles to US Hwy 67, 50 miles to I-55 | US 67 | MO 143, 49, 34, 172 | Co EE, K, M, CC, AA, DD, N, OO, C, FF, U, B, E, P, D, HH, KK, V, A, F, BB, TT, Z, D, Z, RA, W, PP
• Airports: Piedmont Public, Public - Poplar Bluff - 35 mi., Commercial - Cape Girardeau- 70 miles
• Recreation: Clearwater Lake, Wappapello Lake, Sam A. Baker State Park, Markham Springs, Old Greenville, Mark Twain National Forest, Black River, St. Francis River, Coldwater State Forest

Wayne County, with a population of 10,974, is located in the northeastern portion of the Ozark Foothills Region. Some major industries and employers in the county include Windsor Foods, Clark Mountain Nursing Home, Z Manufacturing, McAllister Software, and Greenville Health Care Center. Three healthcare clinics offer high-quality medical assistance to county residents, while four public and two private school systems educate children living in the county. A variety of recreational areas, including Clearwater Lake, Wappapello Lake, Sam A. Baker State Park, Markham Springs, Old Greenville U.S. Historic Site, Mark Twain National Forest, Coldwater State Forest, Black River, and the Saint Francis River are also located in Wayne County.