• Class: 3
• County Seat: Poplar Bluff
• Pop: 42,130 (2020)
• Value: $662,422,890 (2021)
• Sq Mi: 698
• Presiding Commissioner: Vince Lampe, Courthouse located at 100 N. Main Street in Poplar Bluff
• Major Employers: Starting USA, Poplar Bluff Regional Medical Center, Mid-Continent, L&M Manufacturing, Gates Rubber, Briggs & Stratton, Three Rivers College, Public School Systems
• Education: 7 public systems, 6 private systems, Three Rivers College, Poplar Bluff Technical Career Center
• Healthcare: Poplar Bluff Regional Medical Center, John J. Pershing Veterans Administration, St. Francis Medical Center (Coppertop)
• Transportation: I-55 - 50 miles | US 67, 60 & 160 | MO 53, 142, 158, 51 | Co TT, PP, M, F, V, MM, EE, H, HH, UU, AA, WW, N, CC, OO, FF, DD, B, Z, KK, W, JJ
• Airports: Public - Poplar Bluff Municipal Airport, Commercial - Cape Girardeau - 78 miles
• Recreation: Wappapello Lake, Black River, Little Black River, St. Francis River

Butler County, with a population of 42,130, is located in the southeastern portion of the Ozark Foothills Region. Some major industries and employers in the county include Starting USA, Poplar Bluff Regional Medical Center, Mid-Continent Steel & Wire, Three Rivers College, L&M Manufacturing, Briggs & Stratton, and Gates Rubber. Numerous healthcare clinics and three hospitals offer high-quality medical assistance to area residents, while seven public and six private school systems educate children living in the county. Butler County is also the home of Three Rivers College, which has an annual enrollment of approximately 2,700. A variety of recreational activities provided by Wappapello Lake, the Mark Twain National Forest, the St. Francis, Black, and Little Black Rivers are also enjoyed by Butler County residents and visitors to the area.