• Pop: 443
• Mayor: Jason Hill - City Hall 573-224-3911
• City Clerk: Leeanna Quick
• City Treasurer: Leeanna Quick
• Education: Elementary
  High School
• Healthcare: Nearest hospitals - 32 mi. in Poplar Bluff
• Recreation: Lake Wappapello Mark Twain National Forest
  Sam A. Baker State Park
  Old Greenville National Historic Site

Greenville, a community of 443 persons, according to the 2020 census, serves as the county seat for Wayne County. Average temperatures range from 26 degrees Fahrenheit in January to 91 degrees Fahrenheit in July. The Ozark Foothills Regional Planning Commission helps to promote economic development for Greenville.     

Mayor Jason Hill and the four-member city council serve at 108 Walnut Street. The population of Greenville is 443. Citizens are protected by a police department and nine volunteer firemen. The median household income in 2020 was $34,615.

Out of a 7,004-person workforce in Wayne County, the unemployment rate is 8.3 percent as of 2020. The average hourly wage for the county is $15.36. In nearby Piedmont, McAllister Software, Windsor, Clark's Mountain Nursing Center and Z manufacturing can be found. The county's other major employers include Greenville Schools and Clearwater Schools, which employs 160; Greenville Healthcare employs 49. 

Black River Electric Cooperative, headquartered in Fredericktown, provides electric power for Greenville. The city itself provides sewer services for its residents from its four-cell treated lagoon. Public Water Supply District #1 provides water to Greenville residents from its well. Telephone and internet services are provided by AT&T, Big River, Boycom, Sparklight, and Windstream.

Residents of Greenville obtain medical services from Greenville Family Clinic. The nearest healthcare facilities are in Poplar Bluff at Poplar Bluff Regional Medical Center, Coppertop, and Pershing Veterans Administration Medical Center, all 32 miles south.

US Highway 67 runs directly through Greenville. Residents also utilize Missouri Highways 34, D, and E. It is 15 miles to the nearest four-lane highway and Interstate 55 is 50 miles east. The nearest airport is in Piedmont.

Greenville children attend public elementary and high school in town. The nearest public community college, Three Rivers College, is located in Poplar Bluff with an approximate enrollment was 2,700 students. Poplar Bluff Area Technical Career Center is available for students seeking training in vocational skills. Southeast Missouri State University, a public four-year college located in Cape Girardeau, MO, is the nearest higher learning facility. 

There are six Protestant churches serving the community's spiritual needs. Residents do their banking locally at Peoples Community State Bank, First Midwest Bank of the Ozarks, First Missouri State Bank, Southern Bank, and Sterling Bank. There are two public parks within a 20-mile radius for the enjoyment of young and old alike.

Wappapello Lake at Old Greenville is a popular attraction for locals as well as visitors from all over the state. Everyone can enjoy camping, fishing, hiking/fitness/nature trails, boating, swimming, and water skiing. Mark Twain National Forest and Sam A. Baker State Park are near and the Old Greenville Nationall Historic Site is an interesting site.  Annual rainfall for the area averages 42 inches a year.

The community is represented by 144th District State Representative Chris Dinkins (R) and 25th District State Senator Jason Bean (R).  U.S. Representative Jason Smith (R) represents Greenville in the Eighth Congressional District.